国内外推广人类免疫缺陷病毒暴露前预防的主要障碍及其应对措施研究进展

Major obstacles and countermeasures to the wider use of HIV pre-exposure prophylaxis: a review of worldwide research progress

目前,全球艾滋病感染者和患者数不断增加,暴露前预防(pre-exposure prophylaxis, PrEP)作为新型预防人类免疫缺陷病毒(human immunodeficiency virus, HIV)感染的生物医学手段之一,其安全性和有效性已得到了国际研究和人群层面数据的证实。PrEP有助于减缓新发感染数持续上升的趋势,也是目前艾滋病防控的重点。我国目标人群对于PrEP的认知及其应用有限。本文对国内外推广PrEP中所遇障碍以及应对措施进行综述,旨在借鉴国内外PrEP相关实践经验,为我国进一步推广PrEP提供思路。

The number of HIV/AIDS patients and people living with AIDS is increasing globally. Pre-exposure prophylaxis(PrEP), as one of the biomedical methods to prevent HIV infection, helps to slow down the continuous increase of new HIV infections. The efficacy and safety of PrEP have been approved through international studies and population-level data. However, PrEP is a relatively new concept in China and has limited uptake. This review seeks to identify the obstacles and countermeasures during PrEP promotion, in order to provide guidance for popularizing the use of PrEP in China.