宿主细胞表面蛋白在丝状病毒感染中的作用研究进展

Research progress in function of the host cell surface proteins in filovirus entry

识别宿主细胞表面蛋白并与其相互作用是感染性病毒生命周期关键的初始步骤。研究宿主细胞表面蛋白的结构和功能,对揭示病毒和宿主相互作用机制,开发针对宿主细胞表面蛋白的抗体等药物具有重要意义。该文对丝状病毒的宿主细胞表面蛋白进行简要介绍,并对具有药物靶标开发前景的蛋白作重点阐述。

Recognizing and interacting with the host cell surface proteins initiate viral infections. The study on the structure and function of the host cell surface proteins is of great significance for revealing the mechanism of virus-host interactions and developing antibodies or other antagonists targeting these host cell surface proteins. This article outlines filovirus-associated host cell surface proteins and focuses on proteins with potentials to be drug targets.