炔雌醇环丙孕酮片预处理的时间长短对多囊卵巢综合征患者促排卵结局的影响

Influence of the Duration of Ethinylestradiol Cyproterone Tablets Pretreatment on the Outcome of Ovulation Induction in Patients with Polycystic Ovary Syndrome

目的:探讨炔雌醇环丙孕酮片预处理的时间长短对多囊卵巢综合征(PCOS)患者促排卵结局的影响。方法:选择2019年1月至2020年12月江西省妇幼保健院收治的PCOS不孕患者76例,按随机数字表法分为短周期组(38例)、长周期组(38例)。短周期组予以炔雌醇环丙孕酮片(达英-35)预处理≤2个周期,长周期组予以达英-35预处理≥3个周期,预处理后两组采取相同药物进行促排卵治疗。比较两组性激素水平、促排卵治疗情况及促排卵结局。结果:长周期组预处理后促卵泡雌激素(FSH)、雌二醇(E2)高于短周期组,促黄体生成素(LH)、睾酮(T)低于短周期组,促排卵周期使用人绝经促性腺激素(HMG)率低于短周期组,排卵率、临床妊娠率高于短周期组,来曲唑(LE)+HMG周期中,长周期组HMG用量少于短周期组,治疗天数短于短周期组,差异有统计学意义(P<0.05)。结论:达英-35预处理≥3个周期较≤2个周期更能够促使患者激素水平复常,减少HMG用量,缩短促排卵治疗时间,提高排卵率及临床妊娠率。

Objective:To explore the effect of the duration of ethinylestradiol cyproterone tablets pretreatment on the outcome of ovulation induction in patients with polycystic ovary syndrome(PCOS).Methods:A total of 76 cases of PCOS infertility patients admitted to Jiangxi Maternity and Child Health Hospital from January 2019 to December 2020 were selected and divided into shortperiod group(38 cases)and long-period group(38 cases)according to the random number table method.The short-cycle group received Diane-35 pretreatment for≤2 cycles,and the long-cycle group received ethinylestradiol cyproterone tablets(Diane-35)pretreatment for≥3 cycles.After pretreatment,the two groups were treated with the same drugs for ovulation induction therapy.The levels of sex hormones,the treatment of ovulation induction and the outcome of ovulation induction were compared between the two groups.Results:After pretreatment in the long-cycle group,follicle-stimulating estrogen(FSH)and estradiol(E2)were higher than those in the short-cycle group,and luteinizing hormone(LH)and testosterone(T)were lower than those in the shortcycle group.Human menopause was used in the ovulation-stimulation cycle the gonadotropin(HMG)rate was lower than the shortcycle group,and the ovulation rate and clinical pregnancy rate were higher than the short-cycle group.In the letrozole(LE)+HMG cycle,the HMG dosage of the long-cycle group was less than that of the short-cycle group,and the number of treatment days was shorter than the short cycle group,the difference was statistically significant(P<0.05).Conclusion:Diane-35 pretreatment for≥3 cycles is more effective than≤2 cycles to promote the recovery of hormone levels in patients,reduce the dosage of HMG,shorten the treatment time for ovulation induction,and increase the ovulation rate and clinical pregnancy rate.