外泌体及外泌体miRNA在宫颈癌中的研究进展

Research progress of exosome and exosomal miRNA in cervical cancer

宫颈癌作为女性常见恶性肿瘤,近年来其发病情况呈年轻化趋势,且依然是世界范围内危害女性健康的重大问题。外泌体为多囊泡体和细胞膜融合后释放到细胞外的囊泡样小体,可来源于多种细胞,通过运载多种蛋白、脂质、DNA、mRNA和miRNA等生物学功能物质介导细胞-细胞间信息交流。本文主要对外泌体及外泌体miRNA在宫颈癌细胞增殖、转移、诊断和治疗等方面研究进展作一综述,为宫颈癌诊断和治疗提供新思路。

Cervical cancer is a common malignant tumor in women.In recent years,the incidence of cervical cancer is younger,and it is still a major problem endangering women's health in the world.Exosomes are vesicular bodies that are released to the outside of cells after fusion of multi vesicles and cell membranes.They could be derived from a variety of cells and mediate cell-cell information exchange by carrying a variety of biological functional substances such as proteins,lipids,DNAs,mRNAs and miRNAs.In this paper,we reviewed the research progress of exosomes and exosomal miRNAs in invasion,metastasis,diagnosis and treatment of cervical cancer,so as to provide new ideas for the diagnosis and treatment of cervical cancer.