摘要
HBV是一种诱发急、慢性乙型肝炎的DNA病毒,HBV感染是引起肝细胞癌(hepatocellular carcinoma,HCC)的主要原因之一。HBV诱发HCC是一个多因素、多阶段的过程,包括HBV DNA整合到宿主基因中、HBV基因组突变和病毒调节蛋白HBx异常表达等分子机制,异常免疫攻击介导慢性肝损害的免疫机制和DNA甲基化等表观遗传相关机制以及细胞自噬。本文将对近年来HBV诱发HCC的各种机制的研究进展进行综述。
Hepatitis B virus(HBV)is a DNA virus that induces acute or chronic hepatitis B,and it is also one of the main factors causing hepatocellular carcinoma(HCC).HBV-associated HCC development is a multi-factor and multi-stage process,characterized with HBV DNA integration integrated into host genes,HBV genome mutation,abnormal expression of viral regulatory protein HBx,immune attack mediated chronic liver damage,DNA methylation,and hepatocyte autophagy.In this article,we reviews the recent progress in the pathogenesis of HBV-associated HCC.
作者
王可欣
纪冬
WANG Ke-xin;JI Dong(Clinical Medical College of PLA,Anhui Medical University,Beijing 100071,China)
出处
《传染病信息》
2022年第2期166-171,共6页
Infectious Disease Information
基金
“十三五”国家科技重大专项(2018ZX10725-506)
解放军总医院课题(2019MBD-024)。
关键词
乙型肝炎病毒
肝细胞癌
甲基化
自噬
基因突变
免疫逃逸
慢性感染
发病机制
hepatitis B virus
hepatocellular carcinoma
methylation
autophagy
gene mutation
immune escape
chronic infection
pathogenesis
