浙江省居民麻疹抗体水平调查

Serum anti-measles antibody levels among residents in Zhejiang Province

目的了解2018年浙江省居民麻疹抗体水平,为麻疹防控提供依据。方法于2018年采用多阶段整群随机抽样方法,抽取浙江省0~59岁常住居民为调查对象,通过问卷调查收集人口学信息、麻疹病史和含麻疹成分疫苗(MCV)免疫史等资料;检测麻疹病毒IgG抗体水平,计算抗体几何平均浓度(GMC)。分析不同年龄、地区居民麻疹抗体阳性率、保护率和GMC差异。结果调查4189人,其中男性1939人,女性2250人,男女性别比为1∶1.16。麻疹抗体阳性3858人,阳性率为92.10%;达到抗体保护性水平2072人,抗体保护率为49.46%;抗体GMC M(Q_(R))为798.33(1024.06)mIU/mL。麻疹抗体保护率随年龄增长呈下降趋势(χ^(2)_(趋势)=18.067,P<0.001)。不同地区居民麻疹抗体阳性率(χ^(2)=45.090,P<0.001)、保护率(χ^(2)=57.432,P<0.001)和GMC(χ^(2)=88.624,P<0.001)比较,差异均有统计学意义。其中宁波市抗体阳性率较低(85.19%),舟山市抗体保护率(38.98%)和GMC[632.89(909.04)mIU/mL]较低;湖州市抗体阳性率(95.16%)、保护率(58.48%)和GMC[1035.84(1301.77)mIU/mL]均较高。结论2018年浙江省居民麻疹抗体保护率偏低,且随年龄增长呈下降趋势;麻疹抗体水平存在地区差异。

Objective To investigate the serum levels of anti-measles antibody among residents in Zhejiang Province in 2018,so as to provide insights into measles control.Methods Permanent residents aged 0 to 59 years were recruited using the stratified multistage random sampling method in Zhejiang Province in 2018,and subjects'demographic fea⁃tures,medical history of measles and history of immunization with measles-containing vaccine(MCV)were collected us⁃ing a questionnaire survey.The serum level of anti-measles IgG antibody was detected,and the geometric mean concen⁃tration(GMC)of anti-measles IgG antibody was estimated.The seroprevalence,protective rate and GMC of anti-measles IgG antibody were compared among residents at different age groups and regions.Results A total of 4189 residents were enrolled,including 1939 males and 2250 females,with a male to female ratio of 1∶1.16.There were 3858 residents positive for anti-measles IgG antibody,with seroprevalence of 92.10%,and there were 2072 residents with protective antibodies against measles,with a protective rate of 49.46%.The median GMC of anti-measles IgG antibody was 798.33(interquartile range,1024.06)mIU/mL,and the protective rate of anti-measles IgG antibody appeared a ten⁃dency towards a decline with age(χ^(2)_(trend)=18.067,P<0.001).There were significant differences in the seroprevalence(χ^(2)=45.090,P<0.001),protective rate(χ^(2)=57.432,P<0.001)and GMC of anti-measles IgG antibody(χ^(2)=88.624,P<0.001)among residents at different regions,with the lowest seroprevalence of anti-measles IgG antibody in Ningbo City(85.19%),the lowest antibody-protective rate(38.98%)and the lowest GMC[632.89(909.04)mIU/mL]in Zhoushan City,the highest seroprevalence(95.16%),antibody-protective rate(58.48%)and GMC[1035.84(1301.77)mIU/mL]in Huzhou City.Conclusions The protective rate of anti-measles antibody was low and appeared a tendency towards a decline among residents in Zhejiang Province in 2018.There was a region-specific serum level of anti-measles anti⁃body in Zhejiang Province in 2018.