摘要
患者,男,41岁。全身弥漫性红斑伴严重瘙痒1年,多发淋巴结肿大3个月。PET/CT符合淋巴瘤;淋巴结病理:非霍奇金T细胞淋巴瘤,伴不规则、扭曲、脑回样核;皮肤病理:非霍奇金T细胞淋巴瘤,呈蕈样肉芽肿改变。结合患者症状、体征、影像学、病理及免疫组化结果,以及外周血T细胞基因重排均为阳性,诊断为Sézary综合征。给予化疗等一线药物治疗效果不佳。更换为含有维布妥昔单抗的治疗方案后患者红斑消退,瘙痒消失,淋巴结减小,达到完全缓解。
A 41-year-old male presented with diffuse erythema with severe pruritus for 1 year and multiple lymph node enlargement for 3 months. PET/CT image was consistent with lymphoma, pathology of lymph node showed non-Hodgkin T cell lymphoma, with irregular, twisted, and cerebriform nuclei. Skin pathology showed non-Hodgkin T cell lymphoma presenting with mycosis fungoides. Sézary syndrome was diagnosed according the above examinations and T cell gene rearrangement in peripheral blood. The effect of chemotherapy and other first-line drugs was not good, then the treatment regimen containing brentuximab vedotin was given, with good effect of erythema subsided, pruritus disappeared, lymph nodes decreased.
作者
张珂
邵世宏
薛宏伟
陈官芝
肖淑欣
ZHANG Ke;SHAO Shihong;XUE Hongwei;CHEN Guanzhi;XIAO Shuxin(Department of Dermatology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Pathology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China;Department of Lymphology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China)
出处
《中国麻风皮肤病杂志》
2022年第7期466-468,共3页
China Journal of Leprosy and Skin Diseases