组织常驻记忆性T细胞与银屑病复发的研究进展

Update of tissue resident memory T cells and psoriasis recurrence

银屑病是慢性复发性炎症性皮肤病,经常在原皮损消退的部位复发。组织常驻记忆T细胞(tissue resident memory T cells, TRM)能够长期驻留在皮肤中。近年来许多研究表明TRM是银屑病复发的重要原因,有效地抑制TRM可能是控制银屑病复发的关键。但TRM细胞具有抗损伤和抗凋亡特征,给控制复发带来困难。本文就皮肤TRM的产生、驻留以及TRM与银屑病复发的研究进展进行综述。

Psoriasis is a chronic recurrent inflammatory skin disease, which often recurs at the remission site of the primary skin lesions. Tissue resident memory T cells(TRM) can reside in the skin for a long time. In recent years, many studies have shown that TRM plays a crucial role in psoriasis recurrence and effective inhibition of TRM may be the key to control psoriasis recurrence. However, the anti-injury and anti-apoptotic characteristics of TRM make it difficult to control the recurrence. In this paper, we reviewed the production and residence of cutaneous TRM and the relationship between TRM and psoriasis recurrence.