摘要
脓毒症早期过度的炎症反应是脓毒性急性肾损伤(SAKI)发生和发展的关键因素。胆碱能抗炎通路(CAP)通过迷走神经释放乙酰胆碱(ACh)作用于炎性细胞表面α7烟碱型乙酰胆碱受体(nAChR),抑制SAKI和肾内炎症反应,从而发挥肾脏保护作用。本文通过对CAP的组成与CAP调控SAKI的机制进行综述,以期为临床防治SAKI提供新途径。
Excessive inflammatory response at the early stage of sepsis is a key factor in the occurrence and development of sepsis-induced acute kidney injury(SAKI).The cholinergic anti-inflammatory pathway(CAP)releases acetylcholine through the vagus nerve.Acetylcholine acts on the surface of inflammatory cellsα7 nicotinic acetylcholine receptor(α7nAChR)to inhibit SAKI and renal inflammatory response and play a role in renal protection.This article reviews the composition of CAP and the mechanism of CAP regulating SAKI in order to provide a new way for clinical prevention and treatment of SAKI in the future.
作者
史晓翠
李俊聪
李文雄
Shi Xiao-cui;Li Jun-cong;Li Wen-xiong(Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)
出处
《中国急救医学》
CAS
CSCD
2022年第5期448-452,共5页
Chinese Journal of Critical Care Medicine
基金
首都临床诊疗技术研究及示范应用(Z191100006619032)。
