龙葵外敷辅助治疗带状疱疹的临床观察

Clinical observation of adjuvant therapy of herpes zoster by external application of Longkui

目的探讨龙葵外敷辅助西药治疗带状疱疹的临床疗效及安全性。方法将76例患者随机分为治疗组38例和对照组38例,对照组予以泛昔洛韦分散片、维生素B_(1)片、维生素B_(1)注射液治疗,治疗组在对照组基础上予以龙葵外敷,连续治疗14 d。观察2组治疗前后视觉模拟评分法(VAS)评分、睡眠质量(QS)评分和疱疹评价指标(止疱时间、结痂时间、脱痂时间);统计2组用药后不良反应发生情况。结果治疗后,2组VAS评分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05或P<0.01);治疗后,2组患者QS评分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05或P<0.01)。治疗组患者止疱、结痂、脱痂时间均短于对照组,差异有统计学意义(P<0.01)。2组患者不良反应发生情况比较,差异无统计学意义(P>0.05)。结论龙葵外敷辅助西药治疗带状疱疹患者的疗效优于单纯西药治疗,可有效缓解疼痛,提高患者睡眠质量,显著缩短止疱、结痂、脱痂时间,且安全性高,不良反应少。

Objective To explore the clinical efficacy and safety of Longkui external application with western medicine in adjuvant therapy of herpes zoster. Methods A total of 76 patients were randomly divided into treatment group(n=38) and control group(n=38).The control group was given dispersive tablets of famiclovir dispersible tablets, vitamin B_(1)tablets and vitamin B_(1)injection, while the treatment group was given Longkui external application on the basis of the control group, and lasted for 14 days.Visual Analogue Scale(VAS) score, sleep quality score(QS) and herpes evaluation indexes(blister-stopping time, crusting time and scab removal time) were observed before and after treatment in the two groups;the occurrence of adverse reactions after medication in two groups was analyzed. Results After treatment, the VAS scores in both groups were significantly lower than before, and the treatment group was significantly lower after treatment than the control group(P<0.05 or P<0.01);the QS scores in both groups were significantly lower than before treatment, and the treatment group was significantly lower than the control group(P<0.05 or P<0.01).The time of blister-stopping, crusting and scab removal in the treatment group was significantly shorter than that in the control group(P<0.01).There was no significantly significance in the occurrence of adverse reactions between two groups(P>0.05). Conclusion Longkui external application with western medicine in adjuvant therapy of patients with herpes zoster is better than simple western medicine treatment, which can effectively relieve pain, improve the sleep quality of patients, significantly shorten the time of blister-stopping, crusting and scab removal, and has high safety as well as less adverse reactions.