四磨汤联合雷贝拉唑肠溶片及马来酸曲美布汀胶囊治疗胃食管反流病的有效性分析

Analysis on the Effectiveness of Simo Decoction Combined with Rabeprazole Enteric-Coated Tablets and Trimebutine Maleate Capsules in the Treatment of Gastroesophageal Reflux Disease

目的探讨四磨汤联合雷贝拉唑肠溶片及马来酸曲美布汀胶囊治疗胃食管反流病(GERD)患者的效果。方法将我院收治的95例GERD患者随机分为两组。对照组(48例)采用雷贝拉唑肠溶片及马来酸曲美布汀胶囊治疗,观察组(47例)在对照组基础上采用四磨汤治疗,两组均连续治疗6周。对比两组的临床疗效、症状积分及不良反应。结果观察组治疗总有效率为97.87%,高于对照组的83.33%(P<0.05)。治疗后,观察组反酸、烧心、嗳气积分低于对照组(P<0.05)。两组的不良反应比较,差异无统计学意义(P>0.05)。结论四磨汤联合雷贝拉唑肠溶片及马来酸曲美布汀胶囊治疗GERD效果确切,能够缓解患者的临床症状,且不良反应少,利于患者预后。

Objective To explore the effect of Simo Decoction combined with rabeprazole enteric-coated tablets and trimebutine maleate capsules in the treatment of patients with gastroesophageal reflux disease(GERD).Methods 95 GERD patients admitted to our hospital were randomly divided into two groups.The control group(48 cases)was treated with rabeprazole enteric-coated tablets and trimebutine maleate capsules,and the observation group(47 cases)was treated with Simo Decoction on the basis of the control group.Both groups were treated for 6 consecutive weeks.The clinical efficacy,symptom scores and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.87%,higher than 83.33% in the control group(P<0.05).After treatment,the scores of acid reflux,heartburn and belching in the observation group were lower than those in the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Simo Decoction combined with rabeprazole enteric-coated tablets and trimebutine maleate capsules in the treatment of GERD patients has exact effect and can alleviate the clinical symptoms with fewer adverse reactions,which is conducive to the prognosis of patients.