尤瑞克林联合丁苯酞治疗急性缺血性脑卒中后轻中度血管性认知障碍的临床效果

Clinical Effect of Urinary Kallidinogenase Combined with Butylphthalide in the Treatment of Mild-Moderate Vascular Cognitive Impairment after Acute Ischemic Stroke

目的探讨尤瑞克林联合丁苯酞治疗急性缺血性脑卒中后轻中度血管性认知障碍(VCI)的临床效果。方法将70例急性缺血性脑卒中后轻中度VCI患者随机分为对照组(n=35)和观察组(n=35)。对照组采用尤瑞克林治疗,观察组在对照组基础上采用丁苯酞治疗。比较两组的临床疗效、认知功能及不良反应。结果观察组治疗总有效率为91.43%,明显高于对照组的71.43%(P<0.05)。治疗后,两组的MMSE、MoCA评分均高于治疗前,且观察组的MMSE、MoCA评分均高于对照组(P<0.05)。两组的不良反应发生率(14.29%vs.5.71%)比较差异无统计学意义(P>0.05)。结论尤瑞克林联合丁苯酞治疗急性缺血性脑卒中后轻中度VCI效果显著,可有效改善患者的认知功能,且安全性较高。

Objective To explore the clinical effect of urinary kallidinogenase combined with butylphthalide in the treatment of mild-moderate vascular cognitive impairment(VCI)after acute ischemic stroke.Methods 70 patients with mild-moderate VCI after acute ischemic stroke were randomly divided into control group(n=35)and observation group(n=35).The control group was treated with urinary kallidinogenase,and the observation group was treated with butylphthalide on the basis of the control group.The clinical efficacy,cognitive function and adverse reactions were compared between the two groups.Results The total effective rate of the treatment in the observation group was 91.43%,significantly higher than 71.43% in the control group(P<0.05).After treatment,the MMSE and MoCA scores of the two groups were higher than those before treatment,and the MMSE and MoCA scores of the observation group were higher than those of the control group(P<0.05).No statistical difference was found in the incidence of adverse reactions(14.29%vs.5.71%)between the two groups(P>0.05).Conclusions Urinary kallidinogenase combined with butylphthalide has significant effect in the treatment of mild-moderate VCI after acute ischemic stroke,which can effectively improve the cognitive function of patients with higher safety.