健康高龄孕妇妊娠晚期D-二聚体水平及其临床应用价值

Clinical application of D-dimer level in the third trimester of pregnancy in healthy elderly pregnant women

目的 探究D-二聚体在健康高龄孕妇妊娠晚期的表达及其临床意义。方法 回顾性分析2016年1月-2017年7月南方医科大学南方医院住院分娩的2 310例妊娠晚期孕妇临床资料,探讨妊娠晚期孕妇血浆D-二聚体水平与妊娠合并症或并发症的发生及妊娠结局的关系。结果 正常高龄孕妇妊娠晚期的D-二聚体参考值高于正常适龄孕妇,其参考范围上限分别为6.255 mg/L (P95)和8.120 mg/L (P95)。在妊娠结局中,D-二聚体水平与产后出血量呈正相关。结论 妊娠晚期D-二聚体水平对预测孕妇疾病易感性及妊娠结局有一定参考意义,但非其充分条件,不需成为临床工作的常规筛查指标。

Objective To investigate the expression and clinical significance of D-dimer in the third trimester of pregnancy in healthy elderly pregnant women.MethodsThe clinical data of 2 310 women in the third trimester of pregnancy in Nanfang Hospital, Southern Medical University from January 2016 to July 2017 was retrospectively analyzed to explore the relationship between plasma D-dimer level and pregnancy complications or pregnancy outcomes.ResultsThe reference value of D-dimer in advanced-age pregnant women was higher than that of normal pregnant women,and the upper limits of the reference range were 6.255 mg/L(P95)and 8.120 mg/L(P95)respectively. The level of D-dimer was positively correlated with the amount of postpartum hemorrhage in pregnancy outcome.ConclusionsThe level of D-dimer in the third trimester of pregnancy is valuable in predicting maternal disease susceptibility and pregnancy outcome,but it is not a sufficient condition and necessary to be detected routinely in clinical work.