江阴市HIV/AIDS患者首次接受抗病毒治疗效果分析

Effectiveness of antiretroviral therapy for the first time on HIV/AIDS patients in Jiangyin

目的 了解江阴市HIV/AIDS患者首次接受抗病毒治疗(ART)的效果,为进一步完善江阴艾滋病抗病毒治疗工作提供参考依据。方法 收集江阴市2005—2019年首次接受ART治疗的患者在治疗管理数据库信息库中历史卡片及相关信息进行统计分析,比较治疗后病毒载量及CD4^(+)T淋巴细胞(CD4细胞)的变化情况。结果 652例接受ART的患者中,507例(77.76%)病毒学治疗成功,年均CD4细胞计数自然变化速率中位数为90.82个/μL/年;不同年龄段(χ^(2)=10.71,P<0.05;H=10.39,P<0.05)及基线CD4计数层(χ^(2)=37.92,P<0.05;H=9.78,P<0.05)在病毒学治疗及免疫恢复上差异均有统计学意义;显示年龄及基线CD4值是治疗效果的影响因素。结论 年龄及基线CD4值影响ART治疗效果,年龄越大、基线CD4值越低的,病毒学疗效及CD4细胞恢复效果越差,建议感染者应及时介入ART,有利于缩短初始治疗的时间,可进一步提高抗病毒治疗效果。

Objective To analyze the effect of HIV/AIDS patients receiving antiretroviral therapy(ART) for the first time in Jiangyin, and to provide a reference for further improvement of Jiangyin′s AIDS antiretroviral treatment. Methods The historical cards and related information in the treatment management database of Jiangyin City′s cases who received ART for the first time from 2005 to 2019 were collected and statistically analyzed.The changes in viral load and CD4^(+)T lymphocytes(CD4 cells) before and after treatment were compared. Results Among 652 patients receiving ART,507 cases(77.76%) were successful in virological treatment.The median natural change rate of annual average CD4 cell count was 90.82 cells/μL/year(χ^(2)=37.92,P<0.05;H=9.78,P<0.05).There were statistically significant differences in virological treatment and immune recovery between different age groups(χ^(2)=10.71,P<0.05;H=10.39,P<0.05) and different baseline CD4 count layers.The results showed that age and baseline CD4 value were the influencing factors of treatment effect. Conclusion Age and baseline CD4 value can affect the effect of ART treatment.The older the age and the lower the baseline CD4 value, the worse the virological efficacy and the recovery effect of CD4 cells.It is suggested that the infected patients should be involved in ART in time, which is conducive to shorten the time of initial treatment and further improve the effect of antiviral treatment.