冠心病介入术后支架内再狭窄与外周血IL-27、RELM-β水平的关系

Correlation between in-stent restenosis after coronary intervention and levels of IL-27and RELM-βin peripheral blood

目的探究冠心病介入术后支架内再狭窄与外周血白细胞介素-27(IL-27)、抵抗素样分子-β(RELM-β)水平的关系。方法选择2017年5月-2020年9月本院收治的124例冠心病介入术患者作为研究对象,根据冠心病介入术后是否发生支架内再狭窄分为观察组(介入术后支架内再狭窄,64例)和对照组(介入术后未发生支架内再狭窄,60例)两组。观察组又根据Gensini积分为单支组、双支组和多支组,其中单支组31例、双支组20例、多支组13例。检测两组患者实验室生化指标水平,并且进行单因素及logistic回归分析,比较单支组、双支组和多支组外周血IL-27、RELM-β水平,并采用Pearson法对IL-27、RELM-β水平与狭窄支数进行相关性分析。结果两组患者的空腹血糖(FBG)、2 h餐后血糖(2 hPG)、总胆固醇(TC)水平比较,差异无统计学意义(P>0.05);观察组患者的糖化血红蛋白(HbA1c)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(CRP)、IL-27及RELM-β水平均高于对照组,差异具有统计学意义(P<0.05);多因素logistic回归分析显示IL-27及RELM-β是冠心病介入术后发生ISR的独立危险因素;三支组患者的IL-27、RELM-β水平高于双支组与单支组,差异具有统计学意义(P<0.05);双支组患者的IL-27、RELM-β水平高于单支组,差异具有统计学意义(P<0.05);外周血IL-27及RELM-β水平均与冠心病患者术后狭窄支数呈正相关(r=0.506、0.625,P<0.001)。结论外周血IL-27、RELM-β水平的升高是冠心病患者PCI术后ISR发生的独立危险因素,且与其术后冠状病变程度相关。

Objective To investigate the relationship between in-stent restenosis(ISR)and the levels of interleukin-27(IL-27)and resistin-like moleculesβ(RELM-β)in peripheral blood after coronary heart disease intervention.Methods A total of 124 patients received coronary heart disease intervention in our hospital from May 2017 to September 2020 were collected as the study objects.According to the occurrence of in-stent restenosis after surgery they were divided into observation group(n=64,in-stent restenosis after surgery)and control group(n=60 without in-stent restenosis after surgery).Patients in the observation group were divided into single-vessel group(n=31),double-vessel group(n=20)and multi-vessel group(n=13)according to Gensini score(to evaluate the degree of vascular stenosis).Univariate analysis and logistic regression analysis were performed on the biochemical indexes of the observation group and the control group,the levels of IL-27 and RELM-βin the peripheral blood of the single,double and multi-vessel groups were compared,and the correlation between IL-27,RELM-βand the number of stenosis was analyzed by using the Pearson method.Results The levels of glycated hemoglobin(HbA1c),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),C-reactive protein(CRP),IL-27 and RELAM-βin observation group were higher than those in control group(P<0.05),while there were no significant differences in the levels of fasting blood glucose(FBG),2h postprandial blood glucose(2HPG)and total cholesterol(TC)between the two groups(P>0.05).Multivariate logistic regression analysis showed that IL-27 and RELM-βwere independent risk factors for ISR after coronary heart disease intervention.The expression of IL-27 and RelM-βlevels in patients with three branch group were higher than those in double branch group and single branch group(P<0.05);The expression of IL-27 and RelM-βlevels in double branch group were higher than those in single branch group(P<0.05).The levels of IL-27 and RELM-βin peripheral blood were positively correlated with the number of postoperative in-sent restenosis in patients with CHD(r=0.506,0.625,P<0.001).Conclusions Elevated levels of IL-27 and RELM-βin peripheral blood were independent risk factors for ISR in patients with coronary heart disease after PCI,and correlated with the degree of postoperative coronary lesions.