STAT3抑制剂抗肿瘤研究进展

Research Progress in Anti-tumor Activities of STAT3 Inhibitors

信号转导和转录激活因子3(STAT3)是参与多种生物学功能的转录因子,可将细胞外信号传导到细胞核,进而激活靶基因的转录。STAT3异常激活可诱导肿瘤的发生,促进肿瘤的发展,是一个有吸引力的抗癌靶点。目前STAT3抑制剂快速发展,其主要包括STAT3上游信号抑制剂和STAT3直接抑制剂。重点综述近几年靶向STAT3药物的抗肿瘤研究进展。

Signal transducers and activators of transcription 3(STAT3) is a transcription factor involved in a variety of biological functions, which conducts extracellular signals to the nucleus, thus activating transcription of target genes. Abnormal activation of STAT3 induces tumorigenesis and promotes tumor development. It has been shown to be an attractive anticancer target. Currently,studies on STAT3 inhibitors are developing rapidly, mainly including STAT3 upstream signal inhibitors and STAT3 direct inhibitors.Recent research progress in anti-tumor activities of drugs targeting STAT3 has been reviewed in this paper.