脓毒症性心肌功能障碍与高血压病相关性的meta分析

Meta analysis of the relationship between sepsis-induced myocardial dysfunction and hypertension

目的系统评价脓毒症性心肌功能障碍(SIMD)与高血压病的相关性。方法以中英文检索词检索PubMed、Embase、Cochrane Library、中国知网(CNKI)、中国生物医学文献数据库(CBM)以及万方平台从建库到2022年1月的关于SIMD与高血压病相关性的临床研究。采用纽卡斯尔-渥太华质量评分量表(NOS)对文献进行质量评价,应用Stata 12.0软件对纳入的文献进行meta分析。结果经筛选后最终纳入文献16篇,研究对象3758例,meta分析结果显示,具有高血压病史的患者SIMD的发生率更高,差异有统计学意义,亚组分析、敏感性分析均提示结果稳定。结论高血压病是SIMD发生的危险因素,结果具有统计学意义,对具有高血压病史的脓毒症患者早期干预有可能改善预后。

Objective To systematically review the relationship between the sepsis-induced myocardial dysfunction and hypertension.Methods PubMed,Embase,Cochrane Library,China National Knowledge Internet(CNKI),China Biology Medicine(CBM)and Wanfang were searched both with Chinese and English keywords from the establishment of the database to January 2022 on the correlation between sepsis-induced myocardial dysfunction and hypertension.Newcastle-Ottawa Quality Assessment Scale(NOS)was used to evaluate the literature quality,and Stata 12.0 software was used to perform meta-analysis on the included literature.Results After screening,16 literatures were included,a total of 3758 subjects was involved.Meta-analysis results showed that patients with hypertension had a higher incidence of sepsis-induced myocardial dysfunction,and the results were statistically significant.Subgroup analysis and sensitivity analysis suggested stable results.Conclusions Hypertension is a risk factor for sepsis-induced myocardial dysfunction,and the results are statistically significant.Early intervention may improve the prognosis of septic patients.