妇科恶性肿瘤新型纳米递药系统的研究进展

Progress of Research on Novel Nano-drug Delivery System for Gynecological Malignancies

妇科恶性肿瘤主要包括宫颈癌、卵巢癌、子宫内膜癌和妊娠滋养细胞肿瘤等,严重威胁女性的生命健康。传统的妇科恶性肿瘤治疗存在肿瘤复发、侵袭、转移与耐药等问题,治疗过程中使用的常规化疗药物具有靶组织特异性分布能力弱、毒副作用强等缺陷,而快速发展的纳米医学在实现减毒、增效、抑制转移和抗耐药等方面为妇科恶性肿瘤的治疗带来了希望。本文简述几种常见的妇科恶性肿瘤,重点阐述基于新型纳米载体的递药策略以及由纳米递药系统介导的妇科肿瘤治疗策略,以期为治疗妇科恶性肿瘤纳米药物的研发与临床转化提供理论依据。

Gynecological malignancies,mainly including cervical cancer,ovarian cancer,endometrial cancer and gestational trophoblastic tumor,seriously threaten the lives and health of women.Traditional therapies for gynecological malignant tumors have such problems as recurrence,invasion,metastasis and drug resistance.The conventional chemotherapeutic agents used in the treatment process have such defects as poor targeting specificity,strong toxicity,and side effects,while the rapidly developing nanomedicine has brought hope for the treatment of gynecological malignancies in reducing toxicity,enhancing tumor-suppressing effect,limiting tumor metastasis,and inhibiting drug resistance.This article briefly introduces several common gynecological malignancies,and reviews the drug delivery strategies based on novel nanocarriers and the therapeutic strategies for gynecological tumors mediated by nano-drug delivery systems,in order to provide theoretical basis for the development and clinical translation of nanomedicines for the treatment of gynecological malignancies.