摘要
纤维化是机体受到有害因子刺激造成的成纤维细胞过度激活导致的细胞外基质过度沉积。血小板衍生生长因子(PDGF)是纤维化疾病重要介质之一,PDGF/PDGFR通路参与调控心、肝、肾和皮肤等多器官纤维化。综述PDGF/PDGFR信号通路在纤维化疾病中的作用研究进展,以期为纤维化疾病的治疗提供参考。
Fibrosis is the excessive deposition of extracellular matrix caused by excessive activation of fibroblasts stimulated by harmful factors.PDGF is one of the important mediators of fibrotic diseases,and activation of PDGF/PDGFR pathway is involved in the regulation of fibrosis of multiple organs such as heart,liver,kidney and skin.This paper reviews the research progress of PDGF/PDGFR signaling pathway in fibrotic diseases in order to provide reference for the treatment of fibrotic diseases.
作者
纪晓霞
刘红霞
何朝勇
JI Xiaoxia;LIU Hongxia;HE Chaoyong(Department of Pharmacology,School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《药学进展》
CAS
2022年第2期153-160,共8页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金(No.81670425)
中国药科大学“双一流”项目(No.CPU2018GF04)。
