女性绝经后肥胖促进乳腺癌发生及转移的研究进展

Research progress on the incidence and metastasis of breast cancer promoted by obesity in postmenopausal women

研究女性绝经后肥胖与乳腺癌发生进展及预后的相关性,为乳腺癌防治提供理论依据,本综述基于Pubmed、中国知网等文献检索平台,综合多篇国内外相关研究分析发现,肥胖是绝经后女性罹患乳腺癌并导致不良预后的重要危险因素。女性绝经后肥胖者体内雌激素水平升高直接增强乳腺癌细胞的肿瘤学行为;脂肪组织通过释放炎症介质构成有利于肿瘤生长的免疫环境,间接促进肿瘤发展;肥胖还诱导脂肪干细胞分化成肿瘤相关成纤维细胞进而增强乳腺癌细胞增殖及侵袭潜能。肥胖增加绝经后女性患乳腺癌的风险,并诱导乳腺癌转移,促进疾病进展,增加患者癌性死亡风险。该研究明确了女性绝经后人群中肥胖与乳腺癌发生进展及预后的相关性,为乳腺癌的防治提供新思路,具有重要的临床研究价值。

To study the correlation between obesity and breast cancer incidence and progression in postmenopausal female,and provide theoretical instruction for breast cancer prevention and treatment,through being based on literature retrieval platforms such as Pubmed and CNKI,integrating multiple domestic and foreign related documents and various studies,it is found that obesity is one of the most important risk factors for breast cancer incidence and progression in postmenopausal women.On one hand,elevated postmenopausal estrogen levels in obese people directly promote the tumor behavior of breast cancer cells;on the other hand,adipose tissue privides a convenient immune environment for tumor growth by releasing inflammatory mediators,which indirectly promotes tumor development.In addition,obesity also induces the differentiation of adipose stem cell(ASCs)into cancer-associated fibroblasts(CAFs)and enhances the proliferation and invasive potential of breast cancer cells.As mentioned above,obesity increases the risk of breast cancer tumorigenesis and metastasis in postmenopausal women,and increases the risk of cancer-related death in breast cancer patients.The review elaborates the correlation between obesity and breast cancer incidence and progression in postmenopausal women,to provide new ideas for the prevention and treatment of breast cancer,which has essential clinical research value.