短链脂肪酸与肠渗漏

Short-chain Fatty Acids and Intestinal Leakage

短链脂肪酸(SCFAs)是肠道菌群的重要代谢产物,参与肠内物质代谢、介导肠道菌群与肠黏膜上皮细胞的相互作用,与多种疾病的产生关系密切。肠渗漏是各种原因所致肠功能受损的病理状态和疾病过程。SCFAs与肠渗漏的关系研究甚少。本文就SCFAs与肠渗漏的关系及其对疾病的影响作一综述。

Short-chain fatty acids(SCFAs)are important metabolic products of intestinal bacteria,and participate in the metabolism of intestinal materials,mediate the interaction between intestinal bacteria and intestinal mucosal epithelial cells,and are closely related to the occurrence of many diseases.Intestinal leakage is a pathological state and disease process in which intestinal function is impaired due to various reasons.Studies on the relationship between SCFAs and intestinal leakage are few.This article reviewed the relationship between SCFAs and intestinal leakage and its impact on diseases.