摘要
黄褐斑是一种后天获得性色素沉着性疾病,困扰患者的工作和生活。外用经皮给药的主要挑战是药物透过角质层屏障的阻碍。微针作为物理促渗方法和新的递药系统,能够穿透角质层形成特定的药物输送通道,促进了药物的渗透,提高了药物的生物利用度。本文主要总结了微针的特点,并以黄褐斑为切入点,分析微针近年来在黄褐斑领域的应用研究,为后续黄褐斑微针产品的开发提供一定的参考。
Melasma is an acquired pigmentation disease,which plagues the work and life of patients.The main challenge of topical transdermal drug delivery is the barrier of drug penetration through the stratum corneum barrier.As a physical penetration enhancement method and a new drug delivery system,microneedles can penetrate the stratum corneum to form a specific drug delivery channel,which can promote drug penetration and improve drug bioavailability.This paper mainly summarizes the characteristics of microneedles and takes melasma as an entry point to analyze the application research of microneedles in the field of melasma in recent years,and provides certain insights for the subsequent development of microneedle products for melasma.
作者
陶敏
黄巧玲
TAO Min;HUANG Qiaoling(Hangzhou Third People’s Hospital,Hangzhou 310009,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2022年第8期1121-1127,共7页
Chinese Journal of Modern Applied Pharmacy
基金
杭州市卫生健康委员会医学重点学科建设项目(39)
杭州市卫生科技划项目(A20210072,ZD20210039)
杭州市科技计划引导项目(20211231Y030)。
关键词
微针
特点
黄褐斑
应用
microneedles
characteristics
melasma
application
