神经血管单元在脑小血管病中的作用

Role of neurovascular units in cerebral small vessel disease

脑小血管病(cerebral small vessel disease,CSVD)是临床常见的脑血管病,其起病隐匿且临床表现多样。研究表明,神经血管单元(neurovascular unit,NVU)功能失衡与血管内皮功能障碍、血脑屏障通透性改变、胶质细胞活化等病理生理学过程存在多向作用和反复激活现象,在炎症和免疫等因素作用下共同推动CSVD的进展。文章就NVU在CSVD发生和发展中的作用进行了综述。

Cerebral small vessel disease(CSVD)is a common cerebrovascular disease in clinical practice.Its onset is hidden and its clinical manifestations are diverse.Studies have shown that there are pleiotropic effects and recurrent activation phenomenon between the functional imbalance of neurovascular unit(NVU)and a series of pathophysiological processes,such as vascular endothelial dysfunction,blood-brain barrier permeability change and glial cell activation,which jointly promote the progress of CSVD under the action of inflammatory and immune factors.This article reviews the role of NVU in the occurrence and development of CSVD.