摘要
Cytokine release syndrome(CRS)is a major obstacle to the widespread clinical application of chimeric antigen receptor(CAR)T cell therapies.CRS can also be induced by infections(such as SARS-CoV-2),drugs(such as therapeutic antibodies),and some autoimmune diseases.Myeloid-derived macrophages play key roles in the pathogenesis of CRS,and participate in the production and release of the core CRS cytokines,including interleukin(IL)-1,IL-6,and interferon-γ.In this review,we summarize the roles of macrophages in CRS and discuss new developments in macrophage activation and the related mechanisms of cytokine regulation in CRS.
基金
supported by grants from the National Key Research and Development Program of China(Grant No.2020YFA0707704)
the National Key Research and Development Program of China(Grant No.2016YFC1303800)
the Jilin Scientific and Technological Development Program(CN)(Grant No.20190303146SF)
the National Natural Science Foundation of China(Grant No.81874052).