克罗恩病、溃疡性结肠炎患者Th22细胞亚群、IL-6、PCT水平变化及临床意义

Changes and clinical significance of Th22 cell subsets,IL-6,and procalcitonin levels in patients with Crohn's disease and ulcerative colitis

目的探讨克罗恩病、溃疡性结肠炎患者Th22细胞亚群、白细胞介素-6(IL-6)、降钙素原(PCT)水平变化及临床意义。方法回顾性分析鞍钢集团公司总医院2019年4月至2021年3月收治的130例炎症性肠病患者的临床资料,其中克罗恩病患者(克罗恩病组)70例、溃疡性结肠炎患者(溃疡性结肠炎组)60例,选择同期于鞍钢集团公司总医院体检的60例健康人群作为对照组。比较三组受试者以及不同病情程度克罗恩病组、溃疡性结肠炎组患者的Th22细胞、IL-22、IL-6和PCT的表达水平,采用Pearson相关性分析法分析Th22细胞亚群、IL-6、PCT和病情程度的相关性。结果克罗恩病组患者的Th22细胞、IL-22、IL-6、PCT水平明显高于溃疡性结肠炎组和对照组,溃疡性结肠炎组患者的Th22细胞、IL-22、IL-6、PCT水平明显高于对照组,差异均有统计学意义(P<0.05);克罗恩病活动期患者的Th22细胞、IL-22、IL-6、PCT水平明显高于缓解期患者,且溃疡性结肠炎活动期患者的Th22细胞、IL-22、IL-6、PCT水平明显高于缓解期患者,差异均有统计学意义(P<0.05);经Pearson相关性分析结果显示,Th22细胞、IL-22、IL-6、PCT与克罗恩病、溃疡性结肠炎病情程度均呈正相关(P<0.05)。结论克罗恩病、溃疡性结肠炎患者Th22细胞亚群、IL-6、PCT水平明显升高,且和病情程度具有密切关系。

Objective To study the changes and clinical significance of Th22 cell subsets,interleukin-6(IL-6),and procalcitonin(PCT)levels in patients with Crohn's disease and ulcerative colitis.Methods The clinical data of 130 patients with inflammatory bowel disease from April 2019 to March 2021 in Angang Group General Hospital were retrospectively analyzed,including 70 patients with Crohn's disease(Crohn's disease group)and 60 patients with ulcerative colitis(ulcerative colitis group).Sixty healthy people during the same period in the hospital were selected as the control group.The Th22 cells,IL-22,IL-6,and PCT levels were compared among the three groups and among the patients with the different degree of disease in Crohn's disease group or ulcerative colitis group.The correlation between Th22 cell subsets,IL-6,PCT,and disease severity was analyzed by Pearson correlation analysis.Results The Th22 cells,IL-22,IL-6,and PCT levels in Crohn's disease group were significantly higher than those in the ulcerative colitis group and control group,and the Th22 cells,IL-22,IL-6,and PCT levels in the ulcerative colitis group were significantly higher than those in the control group,with statistically significant differences(P<0.05).In Crohn's disease group,the Th22 cells,IL-22,IL-6,and PCT levels in active stage patients were significantly higher than those in remission stage patients,and in ulcerative colitis group,the Th22 cells,IL-22,IL-6,and PCT levels in active stage patients were significantly higher than those in remission stage patients,all with statistically significant differences(P<0.05).Pearson correlation analysis showed that Th22 cells,IL-22,IL-6,PCT were positively correlated with the severity of Crohn's disease and ulcerative colitis(P<0.05).Conclusion Th22 cell subsets,IL-6,and PCT levels are significantly increased in patients with Crohn's disease and those with ulcerative colitis,and they have close relationship with the degree of illness.