胃癌同时性肝转移22例临床手术治疗效果分析

Effect of surgical treatment for 22 patients with gastric cancer liver metastasis

目的探究胃癌同时性肝转移外科手术治疗的临床疗效及不同病理因素对患者预后的影响。方法采用回顾性的研究方法,采集2015年1月—2017年12月安徽医科大学第一附属医院22例胃癌同时性肝转移病人的临床资料,设为R_(0)手术治疗组与R_(1)手术治疗组。其中R_(0)手术治疗组12例患者与R_(1)手术治疗组10例患者均行胃癌切除术,术后均行辅助化疗。所有患者全部按时随访,随访日期截止为2021年9月,中位随访时间累计为64.6(50~80)个月。结果R_(0)手术治疗组与R_(1)手术治疗组22例患者经手术治疗,效果良好,全部顺利出院。两组患者的3年累积生存率分别为33.33%及0.00%,差异具有统计学意义(P<0.05)。结论胃癌同时性肝转移R_(0)手术治疗可以延长病人的生存期,手术切除(R_(0)/R_(1))及病理T分期是影响患者预后的重要因素。

Objective To investigate the clinical effect of surgical treatment for patients with gastric cancer liver metastasis(GCLM)and the influence of different pathological factors on the prognosis.Methods A retrospective study was conducted for the clinical data of 22 patients with GCLM who were admitted to the First Affiliated Hospital of Anhui Medical University from January 2015 to December 2017.They were divided into R_(0) surgical treatment group and R_(1) surgical treatment group.There were 12 patients in the R_(0) surgical treatment group and 10 in the R_(1) surgical treatment group.All of them underwent gastric cancer resection and received adjuvant chemotherapy after surgery.All patients were followed up on time until September 2021,and the median follow-up duration was 64.6(50~80)months.Results 22 patients in the R_(0) group and the R_(1) group were treated with surgery with good effect.All of them were discharged smoothly.The 3-year cumulative survival rates of the two groups were 33.33%and 0.00%,respectively,and the difference was statistically significant(P<0.05).Conclusion The survival of patients with GCLM can be improved by R_(0) surgical treatment.Surgical resection(R_(0)/R_(1))and pathological T staging are important factors affecting the prognosis of patients.