类风湿性关节炎继发骨质疏松120例X线诊断研究

X-ray diagnosis of osteoporosis secondary to rheumatoid arthritis:a report of 120 cases

目的:分析类风湿关节炎患者继发骨质疏松的血清危险标记物,为临床治疗类风湿关节炎,预防骨质疏松症提供依据。方法:选择我院120例类风湿关节炎患者经X线检查继发骨质疏松,同期选择120例健康者,对比类风湿因子、血沉、抗环瓜氨酸肽抗体、C反应蛋白、IL-34、RANKL水平,归纳类风湿关节炎患者继发骨质疏松存在的危险因素。结果:多元Logistic回归分析显示,类风湿关节炎较正常人容易并发骨质疏松,RF、抗环瓜氨酸肽抗体、IL-34、RANKL水平可评估骨质疏松。结论:借助X线诊断可以发现类风湿关节炎,借助典型标记物早期干预可为防治骨质疏松症提供依据。

Objective:To analyze the serum risk markers of secondary osteoporosis in patients with rheumatoid arthritis,and to provide evidence for clinical treatment of rheumatoid arthritis and prevention of osteoporosis.Methods:120 cases of rheumatoid arthritis patients with osteoporosis secondary to X-ray examination were selected in our hospital,and 120 cases of healthy people were selected.The risk factors of rheumatoid arthritis patients with osteoporosis secondary to X-ray examination were summarized by comparing the levels of serum rheumatoid factor RF,ESR,anti cyclic citrullinated peptide antibody(anti CCP),C-reactive protein CRP,IL-34 and RANKL.Results multiple Multivariate Logistic regression analysis showed that rheumatoid arthritis was more likely to be complicated with osteoporosis than normal subjects,and the levels of RF,anti-cycloocitline peptide antibody,IL-34 and RANKL could be used to evaluate osteoporosis.Conclusion:Rheumatoid arthritis can be found by X-ray diagnosis,and early intervention with typical markers can provide evidence for prevention and treatment of osteoporosis.