丹参酮对冠心病心绞痛介入术后患者复发率及血液流变学的影响

Effect of tanshinone on the recurrence rate and hemorheology of patients with coronary heart disease and angina pectoris after intervention

目的观察丹参酮对冠心病心绞痛(CHDAP)介入术后患者复发率及血液流变学的影响。方法将我院收治的120例CHDAP介入术后患者随机分为治疗组与对照组各60例。对照组采用常规西医疗法治疗,治疗组在常规西医疗法基础予以丹参酮ⅡA注射液治疗。两组连续治疗14d。治疗结束后比较两组的疗效,心绞痛复发率,不良反应发生率,治疗前后血液流变学、心功能指标、炎性因子、血脂水平。结果治疗后,治疗组总有效率显著高于对照组(P<0.05),治疗组心绞痛复发率低于对照组(P<0.05),两组不良反应发生率差异不显著(P>0.05);治疗后,两组全血黏度高切、中切、低切和血浆黏度、氨基末端B型钠尿肽原(NT-proBNP)、超敏C反应蛋白(hs-CRP)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、总胆固醇(TC)、甘油三酯(TG)水平与治疗前比较差异均有统计学意义(P<0.05),且组间比较差异有统计学意义,观察组上述指标改善程度均明显优于对照组(P<0.05)。结论丹参酮治疗CHDAP介入术后患者临床疗效较好,能显著降低心绞痛复发率和不良反应发生率,作用机制可能与血液流变学、心功能指标、血脂水平改善,炎性因子下降有关。

Objective To observe the effect of tanshinone on the recurrence rate and hemorheology of patients with coronary heart disease angina pectoris(CHDAP)intervention.Methods A total of 120 patients after CHDAP intervention were randomly divided into treatment group and control group,60 cases in each group.Control group was treated with conventional western medicine,and treatment group was treated with TanshinoneⅡA injection on the basis of control group.Both groups were treated continuously for 14 days.After treatment,the curative effects,the recurrence rate of angina pectoris,the incidence of adverse reactions,blood rheology,cardiac function indicators,inflammatory factors,and blood lipid levels before and after treatment were compared between the two groups.Results After treatment,the total effective rate of treatment group was significantly higher than that of control group(P<0.05),the recurrence rate of angina pectoris in treatment group was lower than that of control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05);whole blood high-cut,mid-cut,low-cut and plasma viscosity,amino-terminal-pro brain natriuretic peptide(NT-proBNP),high-sensitivity C-reactive protein(hs-CRP),high-density lipoprotein(HDL-C),low-density lipoprotein(LDLC),total cholesterol(TC),and triglyceride(TG)levels in both groups were significantly different from those before treatment(P<0.05),and there were statistically significant differences between groups,the degree of improvement in observation group was significantly higher than that in control group(P<0.05).Conclusion Tanshinone has a good clinical effect in treatment of patients after CHDAP intervention.It could significantly reduce the recurrence rate of angina pectoris and the incidence of adverse reactions.The mechanism of action might be related to the improvement of blood rheology,cardiac function indexes,blood lipid levels,and the decrease of inflammatory factors.