摘要
慢性阻塞性肺疾病(COPD)已经成为一个严重的公共卫生问题,以高患病率、高病死率、高致残率及低知晓率为特点。由于其不可逆性,早期预防成为关键。近年来研究发现硫化氢与COPD的发生和预后密切相关,可能作为COPD早期诊断和预后预测生物标志物。本文综述了硫化氢在COPD中的作用和适宜检测方法,探讨了硫化氢作为COPD生物标志物的潜质和应用前景,与其他标志物对比了其优缺点,期望为防治COPD提供新的研究方向。
Chronic obstructive pulmonary disease(COPD)has become a serious public health problem,characterized with high morbidity,high mortality,high disability,and low awareness.Early prevention against COPD is critical due to its irreversibility.Recently,many studies have found that hydrogen sulfide is closely related to the development and prognosis of COPD,and may be used as a biomarker for early diagnosis and prognosis prediction.This review summarizes the detection methods and the role of hydrogen sulfide in COPD,analyses the potential and application prospects of hydrogen sulfide as a COPD biomarker,and compares its advantages and disadvantages with other markers.A new research direction may be provided for the prevention and treatment of COPD.
作者
郑如意
余昕雅
瞿文艳
朱新星
龚洁
陆荣柱
丁明
华亚芳
陆益民
王铁英
Zheng Ruyi;Yu Xinya;Qu Wenyan;Zhu Xinxing;Gong Jie;Lu Rongzhu;Ding Ming;Hua Yafang;Lu Yimin;Wang Tieying(Department of Preventive Medicine and Public Health Laboratory Science,School of Medicine,Jiangsu University,Zhenjiang 212013,China;Department of Respiratory Medicine,Qilidian Community Health Service Center,Zhenjiang 212000,China;Department of Pulmonary and Critical Care Medicine,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China;Department of Respiratory Medicine,the First People′s Hospital of Kunshan,Suzhou 215300,China)
出处
《国际呼吸杂志》
2022年第8期601-606,共6页
International Journal of Respiration
基金
江苏大学2021年大学生创新创业项目(202110299319H)
苏州市医学重点学科基金项目(SZXK201821)
江苏省卫生厅科技项目(YG201403)
苏州市临床重点病种诊疗技术专项项目(LCZX201518)。
关键词
肺疾病
慢性阻塞性
硫化氢
生物标志物
Pulmonary disease,chronic obstructive
Hydrogen sulfide
Biomarker
