人类免疫缺陷病毒感染者NLR、PLR、LMR、d-NLR测定的临床意义

Clinical significance of NLR,PLR,LMR,d-NLR in patients with HIV infection

目的探讨HIV感染患者血细胞计数及相关炎症指标变化特点,为艾滋病的实验诊断以及疗效监测提供实验依据。方法收集2019年1月—2020年6月来本院就诊的人类免疫缺陷病毒感染患者420例,并收集2019年9月—11月健康体检者93例作为对照组;2组分别做血常规检测。结果与对照组相比,HIV感染组白细胞、淋巴细胞、LMR、NMR下降(P<0.05),中性粒细胞、MCV、RDW、NLR、PLR、d-NLR升高(P<0.05);血小板及全身免疫炎症指数差异无统计学意义(P>0.05)。结论NLR、PLR、LMR、NMR等炎症指标可为艾滋病的实验诊断以及疗效监测提供实验依据,对HIV感染者病情判断和疗效观察有一定的指导意义。

Objective To investigate the changes of blood cell count and related inflammatory markers in HIV patients,and to provide experimental basis for the experimental diagnosis and curative effect monitoring of AIDS.Methods A total of 420 cases of human immunodeficiency virus infected patients who came to our hospital from January 2019 to June 2020 were collected,and93 cases of healthy subjects who underwent physical examination from September to November 2019 were collected as the control group.Routine blood tests were performed in the two groups.Results Compared with the control group,leukocytes,lymphocytes,LMR and NMR were decreased in HIV infected group(P<0.05),while neutrophils,MCV,RDW,NLR,PLR and d-NLR were increased in HIV infected group(P<0.05).Platelet decreased,and systemic immune inflammatory index increased,with the differences not statistically significant(P>0.05).Conclusion NLR,PLR,LMR,NMR and other inflammatory markers can provide experimental basis for the experimental diagnosis and efficacy monitoring of AIDS,and have certain guiding significance for the diagnosis of HIV infection and the observation of efficacy.