槐耳制剂治疗消化系统恶性肿瘤的研究进展

Research progress on Robinia pseudoacacia preparation in treating malignant tumors of digestive system

消化系统肿瘤的发病率和病死率在恶性肿瘤中均居前列,目前进展期肿瘤的治疗方式以手术治疗为主,辅以化学治疗、放射治疗、免疫治疗和分子靶向治疗等,传统放射及化学治疗的不良反应较大,难以达到满意疗效。近年来,中草药对于恶性肿瘤的治疗价值备受关注。槐耳作为一种传统中药,广泛应用于多种消化系统恶性肿瘤中,槐耳涉及的抗肿瘤机制主要包括诱导肿瘤细胞的凋亡,延缓肿瘤血管的生成,抑制肿瘤细胞的增殖、侵袭和转移以及逆转肿瘤的耐药性等。目前已作为一种抗肿瘤辅助用药广泛应用于临床,该文就槐耳制剂抗消化系统恶性肿瘤机制作一综述,为临床上治疗消化系统恶性肿瘤提供新的思路及方法。

The morbidity and mortality rates of digestive system tumors rank relatively high among malignant tumors.At present,the treatment methods of advanced tumors are mainly surgery in combination with chemotherapy,radiotherapy,immunotherapy and molecular targeted therapy,etc.Due to severe adverse reactions,traditional radiotherapy and chemotherapy cannot yield satisfactory efficacy.In recent years,the therapeutic value of Chinese herbal medicine for malignant tumors has attracted widespread attention.As a traditional Chinese medicine,Robinia pseudoacacia is widely applied to treat multiple types of malignant tumors of digestive system.The anti-tumor mechanisms of Robinia pseudoacacia include inducing tumor cell apoptosis,delaying tumor angiogenesis,inhibiting tumor cell proliferation,invasion and metastasis and reversing tumor drug resistance.At present,it has been widely utilized as an adjuvant anti-tumors drug in clinical practice.In this review,the mechanism of Robinia pseudoacacia preparation against malignant digestive system tumors was unraveled,providing novel ideas and methods for clinical treatment of malignant digestive system tumors.