α7nAchR对脓毒症患者重要器官损伤控制的研究进展

Research progress ofα7nAchR on control of vital organs damage in patients with sepsis

脓毒症是指因机体对感染的反应失调而导致的危及生命的器官功能障碍。其病情发展迅速,患者预后较差,及时的治疗,尽早控制器官功能损伤能够很大程度上改善患者的预后。α7烟碱型乙酰胆碱受体(α7 nicotinic acetylcholine receptor,α7nAchR)是胆碱能抗炎途径中的主要受体,在危重疾病中发挥重要作用。深入了解α7烟碱型乙酰胆碱受体的作用机制对于寻找治疗脓毒症患者器官功能障碍的有效靶点具有重要意义。

Sepsis is a life-threatening organ dysfunction caused by the body’s dysfunctional response to an infection.The disease develops rapidly and the prognosis of the patients is poor.Timely treatment and early control of organ damage can greatly improve the prognosis of the patients.The a7 nicotinic acetylcholine receptor(a7 nAchR)is the main receptor in the cholinergic anti-inflammatory pathway and plays an important role in critical diseases.An in-depth understanding of the mechanism of action of a7 nAchR is of great significance in searching effective targets for the treatment of organ dysfunction in patients with sepsis.