肠道微生物群落与银屑病炎症细胞因子的相关研究进展

Correlation between intestinal microbial community and psoriasis related inflammatory cytokines

银屑病是一种免疫介导的炎症性皮肤病,影响着全世界1%~3%的人口。银屑病的发病机制是多因素的,遗传和环境因素对银屑病均有显著影响。研究表明肠道微生物群落及相关炎症细胞因子与银屑病的发生和发展密切相关。然而银屑病的发病机制,特别是与肠道微生物群落的相关性,目前仍不明确。本文就肠道微生物群落紊乱,IL-17A、IL-22、TNF-α等相关炎症细胞因子与银屑病发病机制的联系作一综述。

Psoriasis is an immune-mediated inflammatory skin disease that affects 1%–3%of the world’s population.The pathogenesis of psoriasis is multifactorial.Both genetic and environmental factors have significant influence on psoriasis.Recent studies have shown that intestinal microbial community and related inflammatory cytokines are closely related to the occurrence and development of psoriasis.However,the pathogenesis of psoriasis,especially its correlation with intestinal microbial community,is still not fully understood.This review summarizes and analyzes the relationship between intestinal microbial community,IL-17A,IL-22,TNF-αand other inflammatory cytokines and the pathogenesis of psoriasis.