摘要
N^(6)-methyladenosine(m^(6)A)is one of the most abundant and important epigenetic modifications in eukaryotic mRNA.The finding that m^(6)A is a dynamic modification based on methyltransferase and demethylase has sparked a wave of‘epitranscriptomics’,although the term‘epitran-scriptomics’is still controversial.With increasingly intensive research,an increasing number of functions of m^(6)A have been explored,and the results have elucidated that m^(6)A is involved in the splicing,nuclear export,translation,and degradation of mRNA.m^(6)A also has some implications in human disease.For example,promoter-bound m^(6)A methy-lase METTL3 maintains acute myeloid leukemia(AML)through m^(6)A-dependent translation control[1].Recent studies have also found that overexpression of METTL3 promotes the development of AML and those small molecules inhibitors of METTL3 effectively inhibit the development of AML.These results represent an encouraging step towards the development of new drugs to treat AML[2].
基金
the National Natural Science Foundation of China(Grants No.91753201,21721005,and 22037004 to X.Z.
21907077 to Y.W.)
the Postdoctoral Innovative Talent Support Program of China(Grants No.BX20180228 to Y.W.)
China Postdoctoral Science Foundation(Grants No.2019M652691 to Y.W.).
