龈沟液内正畸牙移动相关生物标志物的研究进展

Advances in Biomarkers Related to Orthodontic Tooth Movement in Gingival Crevicular Fluid

龈沟液是存在于龈沟和牙周袋内的一种组织渗透液。对牙齿施加正畸力会引起牙周组织改建和龈沟液内生化介质水平的改变。分析正畸牙移动时龈沟液内特异性生物标志物水平的变化有助于医生了解患者牙周组织的改建状态并监测牙齿移动,从而可以为患者制定个性化的矫治方案、缩短治疗周期和避免不良反应。目前龈沟液内与正畸牙移动相关的生物标志物参与的生物学过程可被分为3大类:炎症、骨吸收与形成、组织损伤与修复。本文拟对具有潜在应用前景的龈沟液内正畸牙移动相关生物标志物作一综述。

Gingival crevicular fluid is a kind of tissue permeation fluid in gingival sulcus and periodontal pocket.The application of orthodontic force to teeth will lead to remodeling of periodontal tissue and changes of biochemical mediators in gingival crevicular fluid.Analyzing the changes of specific biomarkers in gingival crevicular fluid during orthodontic tooth movement is helpful for doctors to understand the remodeling status of patients'periodontal tissue and monitor tooth movement,so as to develop personalized orthodontic treatment plan for patients,shorten the treatment period,and avoid adverse reactions.At present,the biological processes of biomarkers related to orthodontic tooth movement in gingival crevicular fluid can be divided into three categories:inflammation,bone resorption and formation,and tissue injury and repair.This article reviews the potential biomarkers related to orthodontic tooth movement in gingival crevicular fluid.