泌尿系统感染患者病原菌培养和药敏试验结果分析

Results of pathogenic bacteria culture and drug sensitivity test in patients with urinary system infection

目的分析泌尿系统感染患者病原菌培养结果和药敏试验结果。方法抽取2020年1月至2021年6月郑州大学第一附属医院收治的泌尿系统感染患者200例,均采集尿液标本,进行菌株培养鉴定和药敏试验。统计其病原菌分布情况和主要病原菌对常用抗菌药物的耐药性。结果200例患者的送检标本中,培养出病原菌228株,革兰阴性菌较多,其次为革兰阳性菌。大肠埃希菌对哌拉西林、环丙沙星、左氧氟沙星耐药率高达75.00%以上,对头孢他啶耐药率较低;肺炎克雷伯菌对头孢唑林、氨苄西林耐药率均为100%;铜绿假单胞菌对头孢曲松耐药率高达100%,对头孢他啶耐药率为0;鲍曼不动杆菌对哌拉西林、环丙沙星、庆大霉素耐药率均大于60.00%。屎肠球菌对氨苄西林、红霉素、克林霉素耐药率均为100%,粪肠球菌对克林霉素耐药率大于90.00%;二者对万古霉素、利奈唑胺、替考拉宁耐药率均为0。结论泌尿系统感染患者存在多重病原菌感染情况,且不同致病菌对抗菌药物耐药性存在差异,临床应结合病原菌培养和药敏试验结果,合理选择抗菌药物,以提高抗菌效果。

Objective To analyze the results of pathogenic bacteria culture and drug sensitivity test in patients with urinary system infection.Methods A total of 200 patients with urinary system infection who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2020 to June 2021 were selected,and urine samples were collected for bacterial culture identification and drug susceptibility test.The distribution of pathogenic bacteria and the resistance of main pathogens to commonly used antibiotics were counted.Results Among the specimens submitted by 200 patients,228 pathogenic bacteria were cultured,most of which were gram-negative bacteria,followed by gram-positive bacteria.The drug resistance rates of escherichia coli to piperacillin,ciprofloxacin and levofloxacin were more than 75.00%,and the drug resistance rate to ceftazidime was low.The drug resistance rates of klebsiella pneumoniae to cefazolin and ampicillin were 100%.The drug resistance rate of pseudomonas aeruginosa to ceftriaxone was up to 100%,and to ceftazidime was 0.The resistance rates of acinetobacter baumannii to piperacillin,ciprofloxacin and gentamicin were all more than 60.00%.The drug resistance rates of enterococcus faecium to ampicillin,erythromycin and clindamycin were 100%,and the drug resistance rate of enterococcus faecium to clindamycin was more than 90.00%.The drug resistance rates to vancomycin,linezolid and teicoplanin were 0.Conclusions There are multiple pathogenic bacteria infections in patients with urinary system infection,and there are differences in antimicrobial resistance of different pathogenic bacteria.Therefore,rational selection of antimicrobial agents should be combined with the results of pathogen culture and drug sensitivity test to improve antibacterial effect.