急诊STEMI患者冠状动脉介入术中应用替罗非班的疗效观察

Clinical efficacy of tirofiban in coronary intervention on emergency STEMI patients

目的分析急诊ST段抬高型心肌梗死(STEMI)患者冠状动脉介入术中应用替罗非班的临床疗效。方法抽取2018年8月至2021年4月林州市人民医院收治的STEMI患者100例,按随机数字表法将其分为对照组和观察组,每组50例。对照组接受常规冠状动脉介入术治疗,观察组在冠状动脉介入治疗期间加用盐酸替罗非班注射液。观察两组术前及术后6个月心功能指标包括左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、心脏指数(CI)水平,比较两组术后无复流发生情况,观察并记录两组术后6个月内不良心血管事件的发生情况。结果术后6个月与治疗前比较,两组LVEDD值均减小,LVEF、CI值均增大,且观察组变化较大(t=3.042、2.691、2.592,P=0.003、0.008、0.011)。观察组术后无复流、不良心血管事件发生率分别为2.00%(1/50)、2.00%(1/50),低于对照组的16.00%(8/50)、18.00%(9/50),差异有统计学意义(P<0.05)。结论急诊STEMI患者冠状动脉介入术中应用替罗非班效果确切,可有效改善患者心功能,降低术后无复流及不良心血管事件发生率。

Objective To analyze the clinical efficacy of tirofiban in coronary intervention on patients with emergency ST segment elevation myocardial infarction(STEMI).Methods A total of 100 STEMI patients admitted to Linzhou People’s Hospital from August 2018 to April 2021 were selected and divided into control group and observation group according to the random number table method,with 50 cases in each group.The control group received conventional coronary intervention,while the observation group received tirofiban hydrochloride injection during coronary intervention.The levels of cardiac function indexes,including left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),cardiac index(CI)in the two groups were observed before operation and 6 months after operation.The incidences of postoperative no-reflow and adverse cardiovascular events were compared between the two groups.Results Six months after treatment,LVEDD values in both groups were lower than those before treatment,LVEF and CI values were higher than those before treatment,and the change in the observation group was more significant than control group(t=3.042,2.691,2.592;P=0.003,0.008,0.011).The incidences of postoperative no-reflow and adverse cardiovascular events in the observation group were 2.00%(1/50)and 2.00%(1/50),respectively,which were lower than 16.00%(8/50)and 18.00%(9/50)in the control group(P<0.05).Conclusions Tirofiban has a definite effect in emergency STEMI patients during coronary intervention,which can effectively improve cardiac function of patients and reduce the incidence of no-reflow and adverse cardiovascular events.