新型异噁唑啉类化合物氟雷拉纳研究应用现状

Current Status of Research and Application of the Novel Isoxazoline Compound Fluralaner

异噁唑啉类是一类新型抗寄生虫药物,氟雷拉纳(fluralaner)作为异噁唑啉类的成员,对节肢动物γ–氨基丁酸和L–谷氨酸门控氯通道具有选择性抑制作用,目前广泛用于治疗犬和猫的体外寄生虫。与其他类杀虫剂相比,氟雷拉纳具有操作简单、易吸收、安全、高效、长效以及良好的耐受性等特点。本文围绕氟雷拉纳的作用机制与药代动力学特征、临床研究现状以及临床安全性展开充分的总结与归纳,以期为氟雷拉纳在科研、消费以及应用范围等方面提供有价值参考。

Fluralaner,a member of the isoxazolines,is a new class of antiparasitic drugs with selective inhibition of arthropodγ-aminobutyric acid and L-glutamate-gated chloride channels,and is now widely used for the treatment of ectoparasites in dogs and cats.Compared with other types of insecticides,fluralaner has the characteristics of simple operation,easy absorption,safety,high efficiency,long-lasting effect and good tolerance.In this paper,the mechanism of action and pharmacokinetic characteristics,the current status of clinical research and clinical safety of fluralaner are fully summarized.It is expected to provide a valuable reference for the research,consumption and application of fluralaner.