幽门螺杆菌感染与结直肠腺瘤相关性的Meta分析和系统评价

Relationship of Helicobacter pylori infection and colorectal adenoma:a systematic review and Meta-analysis

目的系统评价幽门螺杆菌(Helicobacter pylori,H.pylori)感染与结直肠腺瘤的相关性。方法检索PubMed、EmBase、Web of Science、万方、维普和中国知网,收集有关H.pylori感染与结直肠腺瘤相关性的文献,检索时限为自建库日期至2020年11月,按照纳入及排除标准进行文献筛选、数据提取,并运用NOS量表对病例对照研究类型的文章进行质量评价,横断面研究用AHRQ量表进行质量评价。运用RevMan 5.4软件进行Meta分析,计算比值比(odds ratio,OR)及其95%CI。运用Stata 15.1软件和RevMan 5.4软件进行发表偏倚分析。结果最终共纳入37篇文献,其中H.pylori(+)组54993例,H.pylori(-)组272394例。Meta分析结果显示,结直肠腺瘤的发生风险在H.pylori(+)组与H.pylori(-)组之间差异有统计学意义(OR=1.68,95%CI:1.50~1.88,P<0.01)。结论H.pylori感染与结直肠腺瘤的发生存在相关性。

Objective To evaluate the relationship of Helicobacter pylori(H.pylori)infection and colorectal adenoma through a systematic review and Meta-analysis.Methods The literature search aimed to retrieve all relevant studies published up to Nov.2020 that examined the risk for colorectal adenoma in patients with H.pylori infection.According to the established inclusion criteria,essential data were then extracted from the included studies and further analyzed by a systematic Meta-analysis.RevMan 5.4 software was used for Meta-analysis to calculate the odds ratio(OR)and its 95%CI.The publication bias was analyzed by Stata 15.1 software and RevMan 5.4 software.Results 37 studies including 54993 patients of H.pylori(+)and 272394 patients of H.pylori(-).H.pylori infection was associated with a higher risk for colorectal adenoma(OR=1.68,95%CI:1.50-1.88,P<0.01).Conclusion There is a positive association between H.pylori infection and colorectal adenoma.