正常体质量肥胖与颈动脉硬化及外周动脉硬化的相关性研究

Association of normal weight obesity with carotid atherosclerosis and peripheral arterial stiffness

目的探讨正常体质量肥胖(NWO)与颈动脉硬化(CAS)及外周动脉硬化(PAS)的关系。方法连续收集我院健康管理部18.5 kg/m^(2)≤体质量指数(BMI)<24 kg/m^(2)并完成体脂分析、颈部血管彩超及外周动脉硬化检查者1894人,根据颈部血管彩超及外周血管硬化检查结果分为正常组、单纯CAS组、单纯PAS组及CAS+PAS组,比较亚组间的基本资料,并进行多因素Logistic回归分析。结果单纯CAS组、单纯PAS组及CAS+PAS组NWO比例均明显高于正常组(P均<0.05);单因素分析发现,NWO与CAS及PAS密切相关(P均<0.05);多因素分析发现,NWO可能与CAS发生相关(OR=1.286,95%CI:1.032~1.603,P<0.05),但未能发现NWO与PAS之间有相关性。结论NWO与CAS的发生密切相关,可能是CAS的危险因素。健康体检中应对NWO人群体脂予以关注,及早干预管理,预防CAS的发生。

Objective To investigate the association of normal weight obesity(NWO)with carotid atherosclerosis(CAS)and peripheral arterial stiffness(PAS)in persons received physical examination.Methods A total of 1894 people with normal BMI(18.5−23.9 kg/m^(2))were consecutively enrolled for this study.All these people had completed body fat measurement,carotid artery ultrasound examination and peripheral arterial stiffness detection.Then they were divided into control group,CAS group,PAS group,and CAS+PAS group according to the test results mentioned above.Clinical data were compared between different groups to assess the baseline situation.Besides,Multivariate Logistic regression analysis was performed to determine independent risk factors for atherosclerosis.Results The proportion of NWO in CAS group,PAS group,and CAS+PAS group was significantly higher than that in normal group(P<0.05).Univariate analysis results showed that NWO was correlated with greater risks of both CAS and PAS(P<0.05).However,multiple factors analysis suggested that NWO was not associated with PAS,but with CAS(OR=1.286,95%CI:1.032−1.603,P<0.05).Conclusion NWO is closely related to the occurrence of CAS and may be an independent risk factor for CAS.Attention should be paid to the body fat mass of the NWO population.Early intervention is needed to prevent the occurrence of CAS in these people.