氧化铈纳米颗粒抗病理性血管生成的研究进展

Research progress of cerium oxide nanoparticles on anti-pathological angiogenesis

氧化铈纳米颗粒(CeONPs)是一种应用广泛的稀土氧化物材料,具有自我再生和仿酶活性,在抗肿瘤、抗炎、抑菌、杀菌、免疫调节、抗氧化等生物领域应用广泛。其中,调节血管生成是氧化铈的最重要医学用途之一,病理性血管生成与许多疾病的发生发展密切相关,但常缺乏有效的治疗手段,调控血管生成是治疗的新靶点。本文根据现有相关研究,就CeONPs抗病理性血管生成疾病模型的应用及其潜在的机理研究进展进行综述。文献复习结果表明,CeONPs可抑制肿瘤、慢性炎性病变、视网膜病变、子宫内膜异位症等疾病模型的病理性血管生成,其可能的潜在机理包括调节活性氧的过量产生、影响血管内皮细胞的增殖及凋亡、调节血管生成促进因子的表达以及VEGF磷酸化、下调ASK1-p38/JNK-NF-κB信号通路等。探讨CeONPs的抗病理性血管生成作用,可为CeONPs新材料和药物的研发提供理论指导,并为肿瘤、炎症等与病理性血管生成密切相关疾病的治疗及临床研究奠定基础。

Cerium oxide nanoparticles(CeONPs)is a widely used rare earth oxide material with self-regeneration and bio⁃mimetic activity,which is widely used in anti-tumor,anti-inflammatory,bacteriostatic,bactericidal,immunomodulatory,antioxidant and other biological fields.Among them,regulating angiogenesis is one of the most important medical uses of it.Pathological angiogenesis is closely related to the occurrence and development of many diseases,but there is often a lack of effective treatment.Regulation of angiogenesis is a new target of treatment.Based on the existing research,this paper reviews the application of CeONPs anti-pathological angiogenic disease model and its potential mechanism.The results of literature review show that CeONPs can inhibit pathological angiogenesis in tumor,chronic inflammatory disease,retinopathy,endometriosis and other disease models,and its possible potential mechanisms include regulating the excessive production of reactive oxygen species,affecting vascular endothelial cell proliferation and apoptosis,regu⁃lating the expression of angiogenesis promoting factors and VEGF phosphorylation,down-regulating ASK1-p38/JNK-NF-κB signal pathway,etc..To explore the role of anti-pathological angiogenic of CeONPs can provide theoretical guid⁃ance for the research and development of new materials and drugs of CeONPs,and lay a foundation for the treatment and clinical research of tumors,inflammation and other diseases closely related to pathological angiogenesis.