肠道菌群与2型糖尿病心血管并发症的研究进展

The research progress of gut microbiota and cardiovascular complications of type 2 diabetes mellitus

肠道菌群与宿主之间维持平衡对机体健康有重要意义,肠道菌群失调不仅与T2DM密切相关,对心血管并发症尤其是冠心病(CHD)的发生发展也有重要影响。肠道菌群失调可直接诱发动脉粥样硬化,也可通过高血压、脂代谢紊乱及肥胖症等CHD危险因素间接影响冠状动脉病变。益生菌可纠正肠道菌群失调,对T2DM、CHD发病和预后发挥积极作用。本文对肠道菌群与T2DM心血管并发症的研究进展进行综述。

The balance between gut microbiota and host is of great importance to health.The dysbiosis of gut microbiota plays an important role in both type 2 diabetes mellitus(T2DM)and cardiovascular complications related to diabetes,especially coronary heart disease(CHD).Gut microbiota disturbance can not only promote atherosclerosis directly,but also affect coronary artery disease through the occurrence and development of many risk factors for CHD,including hypertension,dyslipidemia and obesity.Probiotics can improve T2DM and CHD by correcting the abnormality of gut microbiota.Here,we reviewed the research progress of gut microbiota and cardiovascular complications of T2DM.