滋阴熄风方加减治疗老年缺血性脑卒中临床研究

Clinical Study on Modified Ziyin Xifeng Prescription for Senile Ischemic Stroke

目的:观察滋阴熄风方加减治疗老年缺血性脑卒中的临床疗效。方法:选取老年缺血性脑卒中患者64例,按随机数字表法分为观察组和对照组各32例。对照组给予常规西药对症治疗,观察组在对照组基础上给予滋阴熄风方加减治疗。检测2组治疗前后中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分及血清内皮素-1 (ET-1)、中枢神经特异性蛋白(S100-β)水平,并评价临床疗效。结果:观察组总有效率为90.63%,高于对照组65.62%,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分、NIHSS评分比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分、NIHSS评分较治疗前降低,且观察组治疗后中医证候积分、NIHSS评分均低于对照组,差异有统计学意义(P<0.05)。治疗前,2组血清ET-1、S100-β水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清ET-1、S100-β水平较治疗前降低,且观察组治疗后血清ET-1、S100-β水平低于对照组,差异有统计学意义(P<0.05)。结论:滋阴熄风方加减治疗老年缺血性脑卒中阴虚风动证疗效较好,可以缓解患者临床症状,改善神经功能缺损症状,调节血管内皮收缩功能和中枢神经特异性蛋白水平。

Objective: To observe the clinical effect of modified Ziyin Xifeng prescription for senile ischemic stroke.Methods:A total of 64 cases of senile patients with ischemic stroke were selected and divided into the observation group and the control group according to the random number table method,with 32 cases in each group. The control group was given routine symptomatic treatment of western medicine,and the observation group was additionally treated with modified Ziyin Xifeng prescription based on the treatment of the control group. Before and after treatment,Chinese medicine syndrome scores, National Institutes of Health Stroke Scale(NIHSS) scores as well as the levels of endothelin-1(ET-1) and central nervous system specific protein(S100-β) in serum in the two groups were detected. The clinical effects were evaluated.Results:The total effective rate was 90.63% in the observation group,higher than that of 65.62% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores and NIHSS scores between the two groups(P>0.05). After treatment,Chinese medicine syndrome scores and NIHSS scores in the two groups were decreased when compared with those before treatment,and Chinese medicine syndrome score and NIHSS score in the observation group were lower than those in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of ET-1 and S100-β in serum between the two groups(P>0.05). After treatment,the levels of ET-1 and S100-β in serum in the two groups were decreased when compared with those before treatment,and the levels of ET-1 and S100-βin serum in the observation group were lower than those in the control group, the difference being significant(P<0.05).Conclusion: Modified Ziyin Xifeng prescription has a good curative effect in treating yin deficiency with stirring wind syndrome in senile ischemic stroke,which can relieve clinical symptoms,improve neurologic impairment symptoms,and regulate vascular endothelial contraction function and levels of central nervous system specific protein.