脑心通胶囊联合西药治疗急性脑梗死疗效及对血清亲环素A的影响

Curative Effect of Naoxintong Capsules Combined with Western Medicine for Acute Cerebral Infarction and Its Effect on Serum Cyclophilin A

目的:观察脑心通胶囊联合西药治疗急性脑梗死(ACI)的疗效及对血清亲环素A(Cy PA)的影响。方法:选取90例ACI患者,按随机数字表法分为对照组与治疗组各45例。对照组采取西药治疗,治疗组在对照组基础上加用脑心通胶囊治疗,2组均连续治疗2周。比较2组临床疗效,比较2组治疗前后凝血功能指标[血清凝血酶时间(PT)、D-二聚体(DD)、活化部分凝血活酶时间(APTT)]与美国国立卫生研究院卒中量表(NIHSS)评分和Barthel指数评分、炎症因子[单核细胞趋化蛋白1 (MCP-1)、超敏C-反应蛋白(hs-CRP)、CyPA水平]的变化,观察2组不良反应发生率。结果:治疗组临床疗效总有效率为97.78%,对照组为82.22%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组PT、APTT指标值均较治疗前升高,D-二聚体指标值均较治疗前下降(P<0.05);治疗后,治疗组PT、APTT指标值均高于对照组,D-二聚体指标值低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组NIHSS评分均较治疗前下降(P<0.05),Barthel指数均较治疗前上升(P<0.05);治疗后,治疗组NIHSS评分低于对照组,Barthel指数高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组MCP-1、hs-CRP、CyPA水平均较治疗前下降,治疗组上述3项水平均低于对照组,差异均有统计学意义(P<0.05)。对照组不良反应发生率为8.89%,治疗组不良反应发生率为4.44%,2组比较,差异有统计学意义(P>0.05)。结论:脑心通胶囊联合西药治疗ACI疗效较好,能有效改善患者凝血功能,促进神经功能恢复,提高生活能力,降低炎症程度。

Objective:To observe the curative effect of Naoxintong capsules combined with western medicine for acute cerebral infarction(ACI) and its effect on serum cyclophilin A(CyPA). Methods: A total of 90 cases of ACI patients were selected and divided into the control group and the treatment group according to the random number table method,with 45 cases in each group. The control group was treated with western medicine, and the treatment group was additionally treated with Naoxintong capsules based on the treatment of the control group. The clinical effects in the two groups were compared. Before and after treatment, the changes in coagulation function indexes including serum thrombin time(PT),D-dimer(DD) and activated partial thromboplastin time(APTT), scores of National Institutes of Health Stroke Scale(NIHSS)and Barthel indexes as well as levels of inflammatory factors including monocyte chemoattractant protein 1(MCP-1),hypersensitive C-reactive protein(hs-CRP) and CyPA in the two groups were compared. The incidences of adverse reactions in the two groups were observed. Results:The total clinical effective rate was 97.78% in the treatment group,higher than that of 82.22% in the control group,the difference being significant(P<0.05). After treatment,the levels of PT and APTT in the two groups were increased when compared with those before treatment,and DD levels were decreased,differences being significant(P<0.05). After treatment,the levels of PT and APTT in the treatment group were higher than those in the control group,and DD level was lower,differences being significant(P<0.05). After treatment,NIHSS scores in the two groups were decreased when compared with those before treatment and Barthel indexes were increased,differences being significant(P<0.05);NIHSS score in the treatment group was lower than that in the control group,and Barthel index was higher,differences being significant(P<0.05). After treatment,the levels of MCP-1,hs-CRP and CyPA in the two groups were decreased when compared with those before treatment,and the above three levels in the treatment group were lower than those in the control group,differences being significant(P<0.05). The incidence of adverse reactions was 8.89% in the control group and 4.44% in the treatment group, there being no significant difference between the two groups(P>0.05).Conclusion:The therapy of Naoxintong capsules combined with western medicine has a good curative effect in the treatment of ACI,which can effectively improve coagulation function and ability of daily living,promote the recovery of neurological function,and reduce the degree of inflammation.