补肾壮骨法治疗老年骨质疏松性椎体压缩骨折术后临床研究

Clinical Study on Kidney-Supplementing and Bone-Strengthening Method for Senile Patients After Surgery for Osteoporotic Vertebral Compression Fractures

目的:探讨补肾壮骨法对老年骨质疏松性椎体压缩骨折术后患者骨代谢、骨折愈合以及骨密度的影响。方法:选取78例老年骨质疏松性椎体压缩骨折患者进行前瞻性研究,按随机数字表法将患者分为研究组和对照组各39例。2组均行椎体成形术并于术后采取常规对症治疗方案,研究组在此基础上行补肾壮骨法治疗。观察2组术后6周临床疗效和骨折愈合情况。比较2组治疗前后血清中Ⅰ型胶原N端前肽(PINP)、β-胶原特殊序列(β-Crosslaps)、骨钙素N端中分子(N-MID)含量和腰椎处骨密度。结果:治疗后,研究组临床疗效分级情况明显优于对照组(P<0.05),研究组治疗总有效率明显高于对照组(P<0.05)。治疗后,研究组骨折愈合率明显高于对照组(P<0.05),治疗后研究组L;骨密度明显高于对照组(P<0.05)。研究组血清PINP、β-Crosslaps、N-MID含量均明显低于对照组(P<0.05)。结论:补肾壮骨法对老年骨质疏松性椎体压缩骨折术后患者疗效较好,有助于促进患者骨折愈合,降低骨代谢转换并增加骨密度值,改善骨质疏松。

Objective:To discuss the effect of kidney-supplementing and bone-strengthening method onbone metabolism,fracture healing and bone mineral density of senile patients after surgery for osteoporotic vertebral compression fractures.Methods:A total of 78 cases of senile patients after surgery for osteoporotic vertebral compression fractureswere selected for a prospective study and weredivided into the study group and the control group according to the random number table method,with 39 cases in each group.After vertebroplasty,both groups were given routine symptomatic treatment,and the study group was additionally treated with kidney-supplementing and bone-strengthening method. Clinical effects and fracture healing during the first six weeks after the surgery were observed in the two groups. The contents of procollagen type Ⅰ N-propeptide(PINP),β-collagen special sequence(β-CrossLaps),and N-MID osteocalcin(N-MID) in serum as well as lumbar bone mineral density were compared between the two groups before and after treatment. Results:After treatment,clinical effect grading in the study group was obviously better than that in the control group(P<0.05),and the total effective rate in the study group was significantly higher than that in the control group(P<0.05). After treatment,the fracture healing rate in the study group was significantly higher than that in the control group(P<0.05),and bone mineral density of L;in the study group was significantly higher than that in the control group(P<0.05). The contents of PINP,β-Crosslaps,and N-MID in serum in the study group were significantly lower than those in the control group(P<0.05). Conclusion: Kidneysupplementing and bone-strengthening method has a good curative effect on senile patients after surgery for osteoporotic vertebral compression fractures,which is helpful to promote fracture healing,reduce bone metabolic conversion,increase bone mineral density and improve osteoporosis.