佐剂诱导的自身免疫性/炎性综合征研究进展

Research progress of autoimmune/inflammatory syndrome induced by adjuvants

佐剂诱导的自身免疫性/炎性综合征(autoimmune/inflammatory syndrome induced by adjuvants,AISA)是指暴露于佐剂之后机体产生的异常的自身免疫反应。AISA的常见类型主要包括疫苗接种后综合征、硅相关疾病、海湾战争综合征及巨噬细胞肌筋膜炎综合征。但是目前国内对AISA这一概念及发病机制的认识不足,文章结合国内外相关文献,对AISA的概念、常见类型及可能的免疫机制进行综述。

Autoimmune/inflammatory syndrome induced by adjuvants(AISA)refers to the abnormal autoimmune response after exposure to adjuvant.Common types of AISA mainly include post-vaccination phenomena,siliconosis,Gulf War syndrome and macrophagic myofasciitis syndrome.However,there is insufficient understanding of the concept and pathogenesis of AISA in China.This review summarized the concept,common types and possible immune mechanism of AISA.