Sox2 induces glioblastoma cell sternness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
被引量：1
摘要
DNA methylation is a reversible process catalyzed by the ten-eleven translocation(TET)family of enzymes(TET1,TET2,TET3)that convert 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC).Altered patterns of 5hmC and 5mC are widely reported in human cancers and loss of 5hmC correlates with poor prognosis.
同被引文献2
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