摘要
Metastasis and recurrence account for 95%of deaths from nasopharyngeal carcinoma(NPC).Cancer stem cells(CSCs)are regarded as one of the main reasons for tumor cell resistance to clinical therapy,and cancer metastasis or recurrence,while little is known about CSCs in NPC.The present study uncovers a subpopulation of cells labeled as CD45 EPCAM PROCR4 in NPC biopsy samples that exhibit stem cell-like characteristics.A relatively low number of these cells initiate xenograft tumors in mice.
基金
This work was supported by grants from Key Projects of the National Natural Science Foundation of China(81930072)
Excellent Youth Projects of the National Natural Science Foundation of China(81922057)
Youth Project of National Natural Science Foundation of China(81802920).
