摘要
病毒感染对人类的健康和生命构成了持续性的威胁。耐药株的快速出现及新发病毒疫情的爆发亟需研究人员运用新策略快速开发更多新靶标的抗病毒药物,以满足临床防治的需求。本文精选典型研究案例,从药物化学的角度综述了近几年出现的抗病毒药物新靶标与新策略。
Viral infections pose a persistent threat to human health and life. The rapid emergence of drugresistant strains and the outbreak of new viruses require researchers to develop innovative strategies to accelerate the development of more antiviral drugs towards novel targets to meet the clinical needs. This paper selects typical research cases and reviews the novel targets and strategies of antiviral drugs in recent years from the perspective of medicinal chemistry.
作者
徐淑静
丁当
张续杰
刘新泳
展鹏
XU Shu-jing;DING Dang;ZHANG Xu-jie;LIU Xin-yong;ZHAN Peng(Department of Medicinal Chemistry,Key laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第4期903-916,共14页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81773574,82173677)
山东省杰出青年基金资助项目(ZR2020JQ31)
山东省重大科技创新工程项目(2019JZZY021011)。
关键词
抗病毒药物
新靶标
新策略
药物设计
antiviral drug
novel target
novel strategy
drug design
