摘要
肿瘤疫苗作为肿瘤免疫疗法的一种,为癌症治疗提供了新策略。利用纳米仿生材料包被肿瘤抗原,构建纳米仿生型肿瘤疫苗,可实现抗原的靶向递释,具有高效性和安全性等优点。因此,纳米仿生型疫苗成为当今的研究热点。据此,本文综述了新型纳米仿生肿瘤疫苗的研究进展,并介绍了其临床应用及同其他疗法的联合应用情况。
As a kind of tumor immunotherapy, tumor vaccine provides a new strategy for cancer treatment.With nano-biomimetic materials to encapsulate the tumor antigens, the construction of nano-biomimetic tumor vaccine can target the tumor and release antigens, with high efficiency and safety. Therefore, nano-biomimetic vaccine has become a hot research topic. Based on this review, several new nano-biomimetic nanoparticles are summarized, and the clinical applications of the nano-biomimetic vaccine combined with other therapeutic strategies are introduced.
作者
杨玥
王海燕
孙野
孙涛
蒋晨
YANG Yue;WANG Hai-yan;SUN Ye;SUN Tao;JIANG Chen(Key Laboratory of Smart Drug Delivery(Ministry of Education),Minhang Hospital,State Key Laboratory of Medical Neurobiology,Department of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第4期963-975,共13页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(92059110,81872808)
上海人才发展资金项目(2020090)
复旦大学2025卓学计划(to T.S.)
上海学科带头人计划(2018SHZDZX01)
复旦大学-中国科学院上海药物研究所融合基金项目(FU-SIMM-20182006)。
关键词
肿瘤疫苗
免疫治疗
纳米仿生型材料
免疫佐剂
药物靶向递送
tumor vaccine
immunotherapy
nano-biomimetic material
immune adjuvant
targeting drug delivery
